<\/p>\n\n\n\n
Alzheimerova choroba je nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou demence ve Spojen\u00e9m kr\u00e1lovstv\u00ed, uv\u00e1d\u00ed NHS. P\u0159esn\u00e1 p\u0159\u00ed\u010dina nen\u00ed zcela objasn\u011bna, a\u010dkoli l\u00e9ka\u0159i uv\u00e1d\u011bj\u00ed potenci\u00e1ln\u00ed faktory, kter\u00e9 k n\u00ed mohou v\u00e9st, jako je zvy\u0161uj\u00edc\u00ed se v\u011bk, nel\u00e9\u010den\u00e1 deprese, rodinn\u00e1 anamn\u00e9za onemocn\u011bn\u00ed a faktory \u017eivotn\u00edho stylu a stavy souvisej\u00edc\u00ed s kardiovaskul\u00e1rn\u00edmi onemocn\u011bn\u00edmi.<\/p>\n\n\n\n
V posledn\u00edch letech v\u0161ak st\u00e1le v\u00edce v\u011bdeck\u00fdch studi\u00ed podporuje p\u0159esv\u011bd\u010den\u00ed, \u017ee Alzheimerova choroba nen\u00ed jen nemoc, ale infekce.<\/p>\n\n\n\n
Studie z roku 2019 nazna\u010duje, \u017ee Alzheimerova choroba m\u016f\u017ee souviset s onemocn\u011bn\u00edm d\u00e1sn\u00ed.
Podle v\u00fdzkumu veden\u00e9ho hlavn\u00edm autorem Janem Potempou, mikrobiologem z University of Louisville, byla v mozku zem\u0159el\u00fdch pacient\u016f s Alzheimerovou chorobou nalezena p\u0159\u00edtomnost Porphyromonas gingivalis \u2013 patogenu zp\u016fsobuj\u00edc\u00edho chronickou parodontitidu (nebo onemocn\u011bn\u00ed d\u00e1sn\u00ed).<\/p>\n\n\n\n
Gingipainy P. gingivalis (\u010derven\u00e9) mezi neurony v mozku pacienta s Alzheimerovou chorobou.
Gingipainy P. gingivalis (\u010derven\u00e9) mezi neurony v mozku pacienta s Alzheimerovou chorobou. (Cortexyme) p\u0159es sciencealert
P\u0159edchoz\u00ed experiment s my\u0161mi, proveden\u00fd spole\u010dnost\u00ed Cortexyme, Inc., uk\u00e1zal, \u017ee or\u00e1ln\u00ed infekce P. gingivalis vedla k v\u011bt\u0161\u00ed produkci beta-amyloidu \u2013 A\u03b2 \u2013 (lepkav\u00fdch protein\u016f b\u011b\u017en\u011b spojovan\u00fdch s Alzheimerovou chorobou) v mozku hlodavc\u016f.<\/p>\n\n\n\n
\u201eInfek\u010dn\u00ed agens byly ji\u017e d\u0159\u00edve zapleteny do v\u00fdvoje a progrese Alzheimerovy choroby, ale d\u016fkazy o p\u0159\u00ed\u010dinn\u00e9 souvislosti nebyly p\u0159esv\u011bd\u010div\u00e9,\u201c vysv\u011btlil Dr. Stephen Dominy, spoluzakladatel spole\u010dnosti Cortexyme.<\/p>\n\n\n\n
P\u0159i zkoum\u00e1n\u00ed gingipain\u016f, toxick\u00fdch enzym\u016f P. gingivalis, v\u011bdci zjistili, \u017ee vysok\u00e9 hladiny gingipainu byly spojeny s p\u0159\u00edtomnost\u00ed dvou dal\u0161\u00edch protein\u016f, kter\u00e9 ji\u017e byly spojeny s rozvojem Alzheimerovy choroby: tau a ubikvitinu.<\/p>\n\n\n\n
T\u00fdm v\u0161ak tak\u00e9 identifikoval p\u0159\u00edtomnost t\u011bchto toxick\u00fdch gingipain\u016f v mozc\u00edch zem\u0159el\u00fdch pacient\u016f, u kter\u00fdch nebyla Alzheimerova choroba nikdy diagnostikov\u00e1na, tak\u017ee vyvst\u00e1v\u00e1 ot\u00e1zka, zda by jim tato onemocn\u011bn\u00ed byla diagnostikov\u00e1na, kdyby byli na\u017eivu, nebo zda je to Alzheimerova choroba, kter\u00e1 vedla ke \u0161patn\u00e9 p\u00e9\u010di o \u00fastn\u00ed dutinu.<\/p>\n\n\n\n
\u201eNa\u0161e identifikace antigen\u016f gingipainu v mozku jedinc\u016f s Alzheimerovou chorobou a tak\u00e9 s patologi\u00ed Alzheimerovy choroby, ale bez diagn\u00f3zy demence, dokazuje, \u017ee infekce mozku P. gingivalis nen\u00ed d\u016fsledkem \u0161patn\u00e9 p\u00e9\u010de o zuby po n\u00e1stupu demence ani d\u016fsledkem pozdn\u00edho st\u00e1dia onemocn\u011bn\u00ed, ale je \u010dasnou ud\u00e1lost\u00ed, kter\u00e1 m\u016f\u017ee vysv\u011btlit patologii zji\u0161t\u011bnou u jedinc\u016f st\u0159edn\u00edho v\u011bku p\u0159ed kognitivn\u00edm poklesem,\u201c vysv\u011btlili auto\u0159i ve sv\u00e9m \u010dl\u00e1nku.<\/p>\n\n\n\n
Experiment na my\u0161\u00edch tak\u00e9 uk\u00e1zal sn\u00ed\u017een\u00ed produkce amyloidu-beta a neuroz\u00e1n\u011btu v d\u016fsledku slou\u010deniny, kterou spole\u010dnost formulovala s n\u00e1zvem COR388.
Zda by to m\u011blo stejn\u00fd \u00fa\u010dinek i na lidi, bude teprve prozkoum\u00e1no.<\/p>\n\n\n\n
Pexels
\u201eL\u00e9ky c\u00edlen\u00e9 na toxick\u00e9 proteiny bakteri\u00ed zat\u00edm prok\u00e1zaly p\u0159\u00ednos pouze u my\u0161\u00ed, ale vzhledem k tomu, \u017ee za v\u00edce ne\u017e 15 let nebyly objeveny \u017e\u00e1dn\u00e9 nov\u00e9 metody l\u00e9\u010dby demence, je d\u016fle\u017eit\u00e9, abychom testovali co nejv\u00edce p\u0159\u00edstup\u016f k l\u00e9\u010db\u011b nemoc\u00ed, jako je Alzheimerova choroba,\u201c uvedl hlavn\u00ed v\u011bdeck\u00fd pracovn\u00edk David Reynolds z Alzheimer’s Research.<\/p>\n\n\n\n
SD\u00cdLEJTE pros\u00edm tento \u010dl\u00e1nek se svou rodinou a p\u0159\u00e1teli na Facebooku.<\/p>\n","protected":false},"excerpt":{"rendered":"
Alzheimerova choroba je nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou demence ve Spojen\u00e9m kr\u00e1lovstv\u00ed, uv\u00e1d\u00ed NHS. P\u0159esn\u00e1 p\u0159\u00ed\u010dina nen\u00ed zcela objasn\u011bna, a\u010dkoli l\u00e9ka\u0159i uv\u00e1d\u011bj\u00ed potenci\u00e1ln\u00ed faktory, kter\u00e9 k n\u00ed mohou v\u00e9st, jako je zvy\u0161uj\u00edc\u00ed se […]<\/p>\n","protected":false},"author":1,"featured_media":2072,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2071","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tipy"],"aioseo_notices":[],"yoast_head":"\n